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Journal of the Chilean Chemical Society

versión On-line ISSN 0717-9707

Resumen

BRAVO, FELIPE et al. VALIDATION OF A METHOD TO DETECT CENTRAL NERVOUS SYSTEM ACTING DRUGS IN BLOOD BY GC/MS. APPLICATION IN CASES OF DEATH CAUSED BY PHENOTHIAZINES IN THE NORTH OF CHILE. J. Chil. Chem. Soc. [online]. 2014, vol.59, n.3, pp.2603-2605. ISSN 0717-9707.  http://dx.doi.org/10.4067/S0717-97072014000300016.

A simple and rapid analytical method is developed and validated for the determination of antiepileptic and antipsychotic drugs in human whole blood using a solid-phase extraction and quantification by gas chromatography-mass spectrometry (GC/MS). Prazepam was used as internal standard (IS). The specificity, linearity, intra- and inter-assay precision and accuracy, and extraction recovery were fully evaluated. The limits of detection and quantification were in the range of 0.52 - 0.98 μg/mL and 1.56 - 2.97 μg/mL for antiepileptic drugs (pentobarbital, phenobarbital and carbamazepine) and 1.31 - 2.94 ng/mL and 3.98 - 8.89 ng/mL for antipsychotic drugs (chlorpromazine and thioridazine), respectively. The relative standard deviation (RSD) was less than 7.07%, while the intra-day accuracy was < 3.21% and the inter-day was < 8.80%, referred to RSD. The developed methodology was applied in forensic cases of death caused by phenothiazines in the North of Chile during 2010-2012.

Palabras clave : antiepileptic and antipsychotics drugs; gas chromatography; mass selective detector; solid-phase extraction.

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