Abstract

CARCAMO, GERARDO et al. INHIBITION OF QUORUM SENSING BY DRIMANE LACTONES FROM CHILEAN FLORA. J. Chil. Chem. Soc. [online]. 2014, vol.59, n.3, pp.2622-2624. ISSN 0717-9707.  http://dx.doi.org/10.4067/S0717-97072014000300021.

Fifteen native Chilean plants were evaluated against the quorum sensing (QS) biosensor AI-1, Chromobacterium violaceum ATCC 12472. Three extracts showed inhibitory activity of QS: Drymis winteri J.R, Psoralea glandulosa L and Peumus boldus. Purification of secondary metabolites from barks of Drimys winteri showed that drimane sesquiterpenes were the main compounds in the tree. Polygodial, drimenol, isodrimeninol, drimenin, isodrimenin, cinnamolide and valdiviolide were isolated and evaluated in QS inhibition assays. Two α,β unsaturated lactones, cinnamolide and valdiviolide, with the carbonyl on position 12 of the drimane skeleton were found to be inhibitors of QS; other drimane lactones were not active.

Keywords : Quorum sensing; Chromobacterium violaceum; Drimys winteri; Drimane sesquiterpenes.

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