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vol.59 número3MICRO-RAMAN SPECTROSCOPY OF DECORATED POTTERY OF THE DIAGUITA CULTURE FROM IV REGION, CHILE (9TH-15TH CENTURY AD)SYNTHESIS OF N-(HALOGENATED) BENZYL ANALOGS OF SUPERPOTENT SEROTONIN LIGANDS índice de autoresíndice de assuntospesquisa de artigos
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Journal of the Chilean Chemical Society

versão On-line ISSN 0717-9707

Resumo

CARCAMO, GERARDO et al. INHIBITION OF QUORUM SENSING BY DRIMANE LACTONES FROM CHILEAN FLORA. J. Chil. Chem. Soc. [online]. 2014, vol.59, n.3, pp.2622-2624. ISSN 0717-9707.  http://dx.doi.org/10.4067/S0717-97072014000300021.

Fifteen native Chilean plants were evaluated against the quorum sensing (QS) biosensor AI-1, Chromobacterium violaceum ATCC 12472. Three extracts showed inhibitory activity of QS: Drymis winteri J.R, Psoralea glandulosa L and Peumus boldus. Purification of secondary metabolites from barks of Drimys winteri showed that drimane sesquiterpenes were the main compounds in the tree. Polygodial, drimenol, isodrimeninol, drimenin, isodrimenin, cinnamolide and valdiviolide were isolated and evaluated in QS inhibition assays. Two α,β unsaturated lactones, cinnamolide and valdiviolide, with the carbonyl on position 12 of the drimane skeleton were found to be inhibitors of QS; other drimane lactones were not active.

Palavras-chave : Quorum sensing; Chromobacterium violaceum; Drimys winteri; Drimane sesquiterpenes.

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