Resumo

BRITO, IVÁN et al. A NON-CENTROSYMMETRIC POLYMORPH OF 5-HYDROXY-7-METHOXY-2-PHENYLCHROMAN-4-ONE. J. Chil. Chem. Soc. [online]. 2015, vol.60, n.1, pp.2864-2866. ISSN 0717-9707.  http://dx.doi.org/10.4067/S0717-97072015000100020.

The bioactive compound 5-hydroxy-7-methoxy-2-phenylchroman-4-one (pinostrobin, I), was isolated from aerial parts of Nolana ramossisima I.M. Johnst., a Chilean endemic species, using a combination of medium pressure column chromatography and high speed countercurrent liquid-liquid chromatography (HSCCC). The compound crystallized as a non-centrosymmetric polymorph in the orthorhombic chiral space group P2₁2₁2₁. Its structure had been previously reported by Shoja (Acta Cryst. C45, 828, 1989) and Yamovoi et al. (Khim. Prir. Soedin (5), 361, 2001) in the centrosymmetric space groups Pbca and P21/c, respectively.

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