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Journal of the Chilean Chemical Society

versión On-line ISSN 0717-9707

Resumen

ZHAO, QING-HUA et al. INVESTIGATED THE SUPRAMOLECULAR INTERACTION OF TRAMADOL HYDROCHLORIDE WITH P-SULFONATED CALIX[4,6,8]ARENE. J. Chil. Chem. Soc. [online]. 2015, vol.60, n.4, pp.2659-2663. ISSN 0717-9707.  http://dx.doi.org/10.4067/S0717-97072015000400007.

In this paper, the interaction behavior of p-sulfonated calix[n]arene (SCnA) with tramadol hydrochloride was investigated by fluorescence spectra, 1H NMR spectra, and theoretical calculations in aqueous solution. At the optimized conditions, the fluorescence intensity of tramadol hydrochloride showed positive correlation to the concentration of SCnA, which led to a validated, simple, and sensitive fluorescence quenching method for the determination of tramadol hydrochloride was established for the first time. Moreover, the interaction based on SCnA superstructure provided has promising potential for therapeutic monitoring and pharmacokinetics and clinical application

Palabras clave : Tramadol hydrochloride; Spectrofluorometry; Supramolecular interaction; p-sulfonated calyx[n]arene.

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