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Journal of the Chilean Chemical Society

versão On-line ISSN 0717-9707

Resumo

GHAMAMI, SHAHRIAR; GOLZANI, MOJDEH  e  LASHGARI, AMIR. SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL PROPERTIES OF NEW CODEINE FE(III) COMPLEX. J. Chil. Chem. Soc. [online]. 2016, vol.61, n.2, pp.2954-2957. ISSN 0717-9707.  http://dx.doi.org/10.4067/S0717-97072016000200020.

The reaction of FeCl3 hexahydrate with C18H20NO3.PO4 in acetonitrile produced new complex with general formula [Fe(L)]Cl2, (L= codeine). Characterization of the ligand and its complex were made by elemental analysis, FT-IR, 1H-NMR, Raman and UV-visible spectroscopy. This new complex showed antitumor activity against two kinds of cancer cell lines: AGS (Stomach) and MCF-7 (Breast). Cell cytotoxic effects of the ligand and its complex were assayed by MTT and Natural-red tests. The antibacterial activity of ligand and complex against Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus pyogenes and Escherichia coli were also examined.

Palavras-chave : Codeine; Fe(III) complex; Synthesis; Anti-tumor; AGS and MCF-7; Antibacterial.

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