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Journal of the Chilean Chemical Society

versão On-line ISSN 0717-9707

Resumo

ORTIZ, SERGIO et al. SYNTHESIS AND ANTIFUNGAL ACTIVITY OF DIARYL HYDRAZONES FROM 2,4-DINITROPHENYLHYDRAZINE. J. Chil. Chem. Soc. [online]. 2016, vol.61, n.3, pp.3081-3084. ISSN 0717-9707.  http://dx.doi.org/10.4067/S0717-97072016000300015.

A new series of diarylhydrazones derived from 2,4-dinitrophenylhydrazine were synthesized via condensation with aromatic aldehydes whose structures have been determined by mass spectrometry, infrared spectroscopy, and nuclear magnetic resonance spectra. Yields were 50-99%. All compounds were screened in vitro for their antifungal activity. Preliminary results indicated that compounds 3g and 3h exhibited promising antifungal potency. Understanding of the structure of these compounds establishes a preliminary structure-activity relationship to form the basis of further investigation.

Palavras-chave : Antifungal Activity; Diarylhydrazones; Schiff bases.

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