Resumen

LASHKARI, Mojtaba; MAGHSOODLOU, Malek Taher; KARIMA, Mahsa  y  KANGANI, Mehrnoosh. TRIFLUOROACETIC ACID CATALYZED ONE-POT FOUR-COMPONENT DOMINO REACTION FOR THE SYNTHESIS OF SUBSTITUTED DIHYDRO 2-OXYPYRROLES. J. Chil. Chem. Soc. [online]. 2018, vol.63, n.1, pp.3799-3802. ISSN 0717-9707.  http://dx.doi.org/10.4067/s0717-97072018000103799.

Trifluoroacetic acid was applied as an efficient catalyst for the one-pot four-component synthesis of N-aryl/alkyl-3-aminodihydropyrrol-2-one-4-carboxylates via the domino reaction of amines, formaldehyde and dialkyl acetylenedicarboxylates at ambient temperature in methanol. This methodology includes number of advantages such as: short reaction time, clean work-up, use of inexpensive catalyst, high yields and clean work-up. The work-up of this reaction involves only a filtration and a simple washing step with MeOH, and there is no need for column chromatography.

Palabras clave : Trifluoroacetic acid; N-aryl/alkyl-3-aminodihydropyrrol-2-one-4-carboxylates; ambient temperature.

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