Resumo

VARGAS-FRESNEDA, Marcela; GANEM, Flora A.  e  CAMARGO, Rubén J.. Metoclopramide formulation into mucoadhesive polymeric particles for intranasal delivery. Inf. tecnol. [online]. 2020, vol.31, n.2, pp.93-102. ISSN 0718-0764.  http://dx.doi.org/10.4067/S0718-07642020000200093.

Using the modified solvent displacement method, drug-loaded mucoadhesive polymeric particles (Ps) based on Gantrez ®, were prepared and freeze-dried, intended for intranasal delivery of metoclopramide HCl (MCP). Ps characterization was performed by measuring their size (368,0 ± 79,6), the polydispersity index (0,294 ± 0,014) and the Zeta potential (-47,3 ± 4,4) (Nanosizer, Malvern, ZS90). Drug loading (%DL= 12,86) and encapsulation efficiency (%EE= 77,14) were determined by a UV spectrophotometric method (previously validated). In vitro release studies were carried out under sink conditions, using dialysis tubes and orbital shaker. The obtained particles possess attractive technological characteristics in terms of size, drug content and delivering profile, being potentially suitable for nasal administration of metoclopramide.

Palavras-chave : metoclopramide; intranasal delivery; mucoadhesive particles; modified drug delivery.

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