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Información tecnológica

versão On-line ISSN 0718-0764

Resumo

COBO-REALPE, Lorena; COLLAZOS, Carlos A.; CASTELLANOS, Hermes E.  e  HERRERA-MENDOZA, Ketty. Psychopharmacological and analgesic action of selective serotonin reuptake inhibitor antidepressants fluoxetine in female mouse. Inf. tecnol. [online]. 2020, vol.31, n.3, pp.39-50. ISSN 0718-0764.  http://dx.doi.org/10.4067/S0718-07642020000300039.

The main objective of this paper is to establish the potency range and the action mechanism of selective serotonin reuptake inhibition (SSRI) fluoxetine on female CD-1 mice (25-39 kg). Our results indicated that fluoxetine´s antidepressant doses of 16 mg/kg (i.p.), 32 mg/kg (i.p.), and 64 mg/kg (i.p.) had an analgesic and anxiolytic effect without significant results on the spatial memory test. Reduced activity on memory work on specific activities was only observed with a dose of 64 mg/kg (i.p.). This is evidence to suggest that fluoxetine can be more effective with doses that showed an antidepressant effect. It also indicates that fluoxetine can have an analgesic and anxiolytic effect without reducing motor activity on mice. The maximum dose tested on this study showed variations on motor activity of mice suggesting that SSRI fluoxetine can have sedative effects.

Palavras-chave : selective serotonin reuptake inhibition; fluoxetine; analgesic; antidepressant.

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