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Revista chilena de cirugía

versión On-line ISSN 0718-4026


VIAL L, Ismael et al. Prophylactic surgery in breast hereditary cancer syndrome. Rev Chil Cir [online]. 2016, vol.68, n.6, pp.462-466. ISSN 0718-4026.

Introduction: Approximately 5-10% of global cancer has a genetic base. Nowadays it is possible to identify those who have a genetic predisposition for breast cancer, so they can be treated in short term. Objectives: Evaluate how useful is prophylactic surgery on Hereditary Breast cancer Syndrome. Materials and methods: This investigation is a literature review of different research papers from electronic databases such as Scientific Electronic Library Online (SciELO), MedLine-PubMed and UpToDate. The research was made with clinical queries and MeSH terms, specially focused on Hereditary Breast cancer Syndrome. Results: This research shows that prophylactic bilateral mastectomy (PBM) decreases 90% risk of developing breast cancer in BRCA1 and BRCA2 carriers. On the other hand, Salpyngo-oophoferectomy (SO) technique decreases around 53% chances of breast cancer, depending on the associated mutation. Conclusion: Prophylactic surgery has shown an important role decreasing the risk on Hereditary Breast cancer Syndrome. So on, in cases of BRCA1 and BRCA2 carriers we suggest to perform prophylactic surgery.

Palabras clave : Cancer; Surgery; Mutation.

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