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Revista de otorrinolaringología y cirugía de cabeza y cuello

versión On-line ISSN 0718-4816

Resumen

ALVO V, Andrés; BARAHONA A, Luis; ARANIBAR L, Héctor  y  GIANINI V, Romina. Chronic rhinosinusitis: A review of its etiopathogenesis. Rev. Otorrinolaringol. Cir. Cabeza Cuello [online]. 2018, vol.78, n.4, pp.451-462. ISSN 0718-4816.  http://dx.doi.org/10.4067/s0717-75262018000400451.

Chronic rhinosinusitis (CRS) is defined as a symptomatic inflammation of the nasal and paranasal cavities. It is a highly prevalent disease carrying a large associated economic burden, and its current medical treatment achieves symptomatic relief in approximately 50% of patients. Traditionally, it has been classified according to the presence or absence of nasal polyps. However, the mechanisms that lead to the differentiation of both phenotypes are not fully understood. It has been estimated that there are both exogenous and endogenous factors involved that would configure a multifactorial origin of the disease. Given its impact and prevalence, CRS is currently a subject of intense scientific research, in order to accurately determine the targets for a more effective treatment. For this reason, we present an updated review in relation to the underlying pathophysiological mechanisms in CRS.

Palabras clave : Sinusitis; chronic rhinosinusitis; nasal polyps; allergy and immunology; etiology; pathophysiology.

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