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Revista chilena de cardiología

On-line version ISSN 0718-8560

Abstract

LINDEFJELD, Dante et al. Atovastatin does not modify the acutely increased levels of P-selectin and fibrinogen induced by maximal physical exercise. Rev Chil Cardiol [online]. 2010, vol.29, n.1, pp.47-56. ISSN 0718-8560.  http://dx.doi.org/10.4067/S0718-85602010000100005.

Background: Chronic statin therapy ¡s known to decrease ¡nflammation and platelet aggregation. However, little data exist regarding acute effect of statíns upon these variables. Exercise can be used to induce ¡nflammation and platelet aggregation. Aim: to determine the acute effect ofatorvastatin upon plasma levels of ultra sensitive C reactive protein (US-PCR), fibrinogen and P selectin before, immediately after and 24 hr following a maximal exercise test in healthy subjects. Methods: This was a double blind, randomized prospective study Fifty healthy male subjects (aged 18to 50years) received atorvastatin 80 mg or placebo daily for 7 days. US-PCR, fibrinogen, P-selectin, blood lipids, total creatin-kinase (CK) and transaminases were determined pre and immediately after maximal treadmill exercise. Repeat determinations were performed 24 following the test. Results were analyzed using the SPSS statisticalpackage, and are expressed as mean ± SD. Student's t and repeated measures ANOVA were used as appropriate. Results: 44 subjects completed the study (atorvastatin =24; placebo= 20). LDL cholesterol decreased from 97±27 to 62±31 mg/dl in the atorvastatin group (p<0.001). US-PCR, After 1 week, Fibrinogen and P-selectin were not significantly modified from baseline, and no differences were observed between groups (atorvastatin vs. control). However, fibrinogen increased 8% from baseline to immediately post exercise (341 ±56 vs. 368±65mg/dl (95% CI. 21/.3 - 33.6). 24hr after exercise, fibrinogen levels returned to baseline. Similar changes were observed for P-selectin (25±1.5, 28±1.7 ng/dl, baseline and post exercise respectively p<0.01), again returning to baseline 24hr after exercise. No significant changes were observed for US-PCR after exercise in neither group. CK increased 43% in the atorvastatin group and 12% in controls (NS). Conclusion: Atorvastatin 80 mg/day during 7 days in healthy subjects did not inhibit exercise-increased fibrinogen and P-selectin levels.

Keywords : Atorvastatin; P-selectin; fibrinogen; exercise.

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