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Revista chilena de cardiología

versión On-line ISSN 0718-8560

Resumen

LAGOS, Jenny et al. Association of serum lipid levéis and mitochondrial DNA Amerindian haplogroups in hypercholesterolemic subjects receiving atorvastatin. Rev Chil Cardiol [online]. 2010, vol.29, n.2, pp.208-213. ISSN 0718-8560.  http://dx.doi.org/10.4067/S0718-85602010000200006.

Background: Therapeutic response to statins is influenced by age, gender and ethnicity. The genetic background of the Chilean population is predominantly Amerindian, defined by the presence of mitochondrial DNA (mtDNA) Amerindian haplogroups A, B, C and D Amerindian haplogroups and serum lipid levéis in hypercholesterolemic Chilean subjects receiving atorvastatin Methods: 42 subjects from southern Chile were included. The presence of mtDNA Amerindian haplogroups was evaluated by PCR-RFLP; in addition, total cholesterol, triglycerides, HDL-cholesterol and LDL-cholesterol were measured before and after treatment with atorvastatin 10 mg/day. Aim: to evaluate a possible association of mtDNA. Ameridian haplogroups and serum lipid levels in hypercholesterolemic Chilean subjects neceiving atorvastatin. Resulte: 88.1% of subjects exhibited some Amerindian haplogroup. No relation of lipid levéis with haplogroups was observed before treatment. Interestingly, haplogroup B individuáis had higher levéis of total cholesterol compared to other haplogroups after treatment (haplogroup B : 254 ± 30 mg/dl; C : 213 ± 48 mg/dl; D : 230 ± 50 mg/dl, p=0.0319). Corresponding levéis for LDL-cholesterol after treatment in the three groups were 157 ± 34,118 ±45 and 135 ±42 mg/ di, respectively, p=0.0344. Conclusión: Compared to other haplogroups, haplogroup B is associated to higher levéis of lipids after treatment with atorvastatin. For the first time, these findings suggest that the presence of mtDNA haplogroup B determines a dimished response to atorvastatin in Chilean subjets with an Amerindian genetic background.

Palabras clave : mtDNA haplogroups; hypercholesterolemia; atorvastatin.

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