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vol.32 número1INFARTO AGUDO AL MIOCARDIO EN PACIENTES MENORES DE 40 AÑOS: CARACTERISTICAS CLÍNICAS, ANGIOGRÁFICAS Y ALTERNATIVAS TERAPÉUTICAS índice de autoresíndice de assuntospesquisa de artigos
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Revista chilena de cardiología

versão On-line ISSN 0718-8560

Resumo

BARTOLUCC¡, Jorge et al. AUTOLOGOUS BONE MARROW CELL TRANSPLANTATION IMPROVES EJECTION FRACTION IN PATIENTS WITH DILATED CARDIOMYOPATHY OF DIVERSE ETIOLOGIES: PROYECTO INNOVA CHILE Nº 205-4350. Rev Chil Cardiol [online]. 2013, vol.32, n.1, pp.11-20. ISSN 0718-8560.  http://dx.doi.org/10.4067/S0718-85602013000100001.

Background: Recent studies indicate that intra-coronary delivery of autologous bone marrow mono-nuclear cells (BMCs) improves the ejection fraction (LVEF) and other clinical markers in patients with heart failure (HF). Aim: To evaluate the safety and efficacy of intraco-ronary delivery of autologous BMCs in patients with HF in dilated phase under optimal medical treatment. Method: Of 23 consecutive patients who met the inclusion criteria, 12 were assigned to autologous BMCs intracoronary transplantation, receiving a mean dose of 8.19±4.43 x 106 CD34+ cells (BMCs group). The remaining patients received only standard therapy (control group). All patients were evaluated by Electrocardiogram, Echocardiography, Holter Monitoring, Cardiac Magnetic Resonance Imaging, Stress Testing, Ventricular Late potetials, Heart Rate Variability, and regular clinical examination at baseline and at follow-up (3, 6 and 12 months). Repeated measures ANOVA and Bonferroni testing were used for statistic analysis. Results: The BMCs group presented a significant increase in EF at sixth months (26.75±4.85 vs. 37.82±6.97%, p=0.001) and 12 months post-transplant (26.75±4.85 vs. 37.27±7.51%, p=0.002). There was a significant improvement in functional (NYHA) in the transplanted group at 6 and 12 months (p<0.001). There were no significant changes concerning left ventricular volumes, heart rate variability and exercise stress testing. We observed no improvement of these variables in the control group. There were no complications related to the BMCs transplant. Conclusions: Intracoronary infusion of auto-logous BMCs, in addition to standard therapy, was associated with significant improvement of left ventricular function at 12 months in patients with HF. We observed no complications relative to the procedure.

Palavras-chave : Bone marrow cell transplantation; Left ventricular function; Heart failure.

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