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Revista chilena de cardiología

On-line version ISSN 0718-8560

Abstract

CORDOVA, Sebastián; LEMUS, David; ROSAS, Carlos  and  CALDERON, José Luis. Acetyl-salicylic acid inhibits angiogenesis in alanto chorionic chicken membrane. Rev Chil Cardiol [online]. 2016, vol.35, n.2, pp.127-132. ISSN 0718-8560.  http://dx.doi.org/10.4067/S0718-85602016000200005.

Background: Acetylsalicylic acid (ASA) is widely used in the treatment of various cardiovascular disorders. In vitro, AAS decreases angiogenesis, through cyclo-oxigenase-1 blockade while keeping active the adherent endothelial zone, direct toxicity and other signaling pathways. Hypothesis: AAS at therapeutic anti plaquetary doses exerts an anti-angiogenic effect in the alanto choronic chicken membrane (ACM) Method: 46 fertilized eggs form White Leghorn hens were incubated at 37oC. 10 uL of 0.1% Dimethyl sulfoxide +Ml 19 with no drug were used as control, while experimental groups received ASA and Salicylic acid (SA), 2mM. After fixation, samples were analyzed in a blind fashion Results: The mean number of vessels was 21.8 for controls, 11.3 and 10 for ASA 2mM and ASA 5mM, respectively. Corresponding values for SA 2 and SA 5mM were 15.6 and 12.4, respectively. Thus, a statistically significant (ANOVA and Student's t) decrease in the number of vessels was observed in both ASA groups. SA showed had a greater potential for anti-angiogenesis in a dose dependent way. Conclusion: This study shows that ASA in therapeutic concentrations has an anti-angiogenic effect in a physiologic model in vivo.

Keywords : Aspirin; salicylic acid; angiogenesis; chorioallantoic membrane; chicken.

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