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Revista clínica de periodoncia, implantología y rehabilitación oral

versión On-line ISSN 0719-0107


CHUMPITAZ-CERRATE, Víctor et al. Influence of ambient oxygen pressure on guided bone regeration. Rev. Clin. Periodoncia Implantol. Rehabil. Oral [online]. 2017, vol.10, n.2, pp.111-114. ISSN 0719-0107.


To evaluate the influence of the variation in ambient oxygen pressure on guided bone regeneration in guinea pigs.

Material and method:

A total of 32 male guinea pigs weighing 750±50g were assigned into two groups of 16 (group A: studied at 150 metres above sea level in the city of Lima and oxygen pressure of 157mmHg; group B: was at 3230 meters above sea level in the city of Jauja and an oxygen pressure of 107mmHg). Bone defects of 5×6mm were induced in the jaw in both groups through extra-oral surgical access. The defect in 8 guinea pigs of each group were covered with a porcine resorbable collagen membrane, but not in the other animals. The osteoblast and osteocyte cell counts were evaluated at 15 and 30 days post-operatively.


At 15 and 30 days, in the groups studied at height and with the membrane applied, the osteoblast count was 71±12.1 cells/field, and 83±7.2 cells/field, respectively, and an osteocyte count of 34.5±6.6 cells/field, and 25±7.6 cells/field, respectively. These groups had a higher number of bone cells in all the comparisons, but there were no statistically significant differences (P>.05).


There was a tendency to form a greater amount of bone cells was found in the samples treated with bone regeneration and exposed to altitude compared to those at sea level.

Palabras clave : Oxygen; Bone regeneration; Cell hypoxia; Hypoxia inducible factor-1.

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