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Revista clínica de periodoncia, implantología y rehabilitación oral

versión On-line ISSN 0719-0107

Resumen

ROJAS, Miguel A. et al. Distribution of fimA genotypes of Porphyromonas gingivalis in Chilean patients with chronic periodontitis. Rev. Clin. Periodoncia Implantol. Rehabil. Oral [online]. 2017, vol.10, n.3, pp.141-144. ISSN 0719-0107.  http://dx.doi.org/10.4067/S0719-01072017000300141.

Background:

Porphyromonas gingivalis fimA gene is a key virulence factor and has been associated with development and progression of periodontal diseases.

Aim:

To quantify the levels of P. gingivalis and the prevalence of fimA genotypes in Chilean patients with different severity of chronic periodontitis.

Methodology:

One hundred and thirty five subgingival samples from 45 adults (15 with slight, 15 with moderate and 15 with severe chronic periodontitis, respectively) were analyzed by qPCR for P. gingivalis and fimA genotypes (I-V and Ib).

Results:

P. gingivalis was detected in 73.3% of patients (46.6%, 73.3% and 100% of patients with slight, moderate and severe chronic periodontitis, respectively). The genotype fimA was detected in 66% of positive subjects for P. gingivalis, whereas fimA IV and I were the most prevalent genotypes. In addition, fimA IV was detected in 75% and fimA I in 62.5% of severe and moderate cases, respectively. Increased levels of fimA IV were associated with severe chronic periodontitis.

Conclusions:

These findings suggest that there is a high prevalence of P. gingivalis and its fimA IV and I genotypes in chronic periodontitis patients. Furthermore, fimA IV was associated with severe chronic periodontitis in this Chilean population.

Palabras clave : Chronic periodontitis; Biofilms; Bacterial fimbriae.

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