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Revista clínica de periodoncia, implantología y rehabilitación oral

versión On-line ISSN 0719-0107


PRINCIPE-DELGADO, Yuliana; MALLMA-MEDINA, Adrián  y  CASTRO-RODRIGUEZ, Yuri. Effectiveness of fibrin-rich plasma and collagen membrane in guided bone regeneration. Rev. Clin. Periodoncia Implantol. Rehabil. Oral [online]. 2019, vol.12, n.2, pp.63-65. ISSN 0719-0107.


of this study was to determine the effectiveness of two biomaterials, fibrin-rich plasma (PRF) and collagen membrane in guided bone regeneration.

Materials and method:

Thirty male guinea pigs were used, weighing between 900 and 1100 g., divided into three groups of 10 guinea pigs each (Group A: control, group B: collagen membrane and group C: fibrin-rich plasma). Each group had a 2-mm unilateral mandibular bone defect. Group A did not receive any biomaterial; in groups B and C the biomaterials were used in the bone defects. After 15 and 30 days of healing, histological sections were performed to evaluate the amount of fibroblasts, osteocytes and osteoblasts.


After 15 days, group C formed 40.6 ± 8.08 osteocytes / camp and group B 27.6 ± 4.72 (p <0.05); After 30 days, group C: 30.6 ± 11.55 and group B: 23.6 ± 3.85 (p> 0.05).


During the first 15 days of healing, PRF induces a greater cellular proliferation than the other groups in a significant way; after 30 days, the proliferation is similar to the collagen membrane group without significant differences.

Palabras clave : Bone regeneration; Fibrin; Collagen; Guinea pigs.

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